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KMID : 0811720140180010033
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Korean Journal of Physiology & Pharmacology
2014 Volume.18 No. 1 p.33 ~ p.39
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Anti-Inflammatory and Anti-Superbacterial Properties of Sulforaphane from Shepherd’s Purs
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Choi Woo-Jin
Kim Seong-Keun
Park Hee-Kuk
Sohn Uy-Dong
Kim Won-Yong
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Abstract
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Shepherd’s purse, Capsella bursa-pastoris (L.) Medik., has been considered a health food for centuries in Asia and is known to contain the isothiocyanate compound sulforaphane. In this study, we evaluated the anti-inflammatory and antibacterial properties of a sulforaphane-containing solution (SCS) isolated from shepherd’s purse. SCS had significant anti-inflammatory activity indicated by the decreased levels of nitric oxide (NO), cytokines (interleukin 1β [IL-1β], IL-6, and IL-10), and prostaglandin E2 (PGE2) in lipopolysaccharide-stimulated RAW 264.7 murine macrophages. In addition, SCS decreased the inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) levels, which confirmed the anti- inflam-matory activity of SCS. Further, SCS inhibited vancomycin-resistant enterococci (VRE) and Bacillus anthracis. The minimal inhibitory concentration was 250 μg/ml for VRE and 1,000 μg/ml for B. anthracis. Taken together, these data indicate that SCS has potential anti-inflammatory and anti- superbacterial properties, and thus it can be used as a functional food or pharmaceutical.
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KEYWORD
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Anti-inflammatory effec, Antimicrobial activity, Cytokine, RAW 264.7 murine macrophages, Shepherd’s purse, Sulforaphane
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